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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sudeste. |
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Data corrente: |
09/12/2021 |
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Data da última atualização: |
09/12/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
LOPES, P. D.; OKINO, C. H.; FERNANDO, F. S.; PAVANI, C.; MARIGUELA, V. C.; MONTASSIER, M. DE F. S.; MONTASSIER, H. J. |
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Afiliação: |
PRISCILA DINIZ LOPES, UNESP; CINTIA HIROMI OKINO, CPPSE; FILIPE SANTOS FERNANDO, UNESP; CAREN PAVANI, UNESP; VIVIANE CASAGRANDE MARIGUELA, UNESP; MARIA DE FÁTIMA SILVA MONTASSIER, UNESP; HÉLIO JOSÉ MONTASSIER, UNESP. |
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Título: |
Comparative evaluation of immune responses and protection of chitosan nanoparticles and oil-emulsion adjuvants in avian coronavirus inactivated vaccines in chickens. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Vaccines, v.9, n.12, 1457, 2021. |
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ISSN: |
2076-393X |
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DOI: |
https://doi.org/10.3390/vaccines9121457 |
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Idioma: |
Inglês |
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Conteúdo: |
Efficient vaccines are the main strategy to control the avian coronavirus (AvCoV), although several drawbacks related to traditional attenuated and inactivated vaccines have been reported. These counterpoints highlight the importance of developing new alternative vaccines against AvCoV, especially those able to induce long-lasting immune responses. This study evaluated and compared two inactivated vaccines formulated with AvCoV BR-I variants, one composed of chitosan nanoparticles (AvCoV-CS) and the second by Montanide oily adjuvant (AvCoV-O). Both developed vaccines were administered in a single dose or associated with the traditional Mass attenuated vaccine. The AvCoV-CS vaccine administered alone or associated with the Mass vaccine was able to induce strong humoral and cell-mediated immune (CMI) responses and complete protection against IBV virulent infection, wherein single administration was characterized by high IgA antibody levels in the mucosa, whereas when associated with the Mass vaccine, the serum IgG antibody was predominantly observed. On the other hand, single administration of the oily vaccine presented poor humoral and CMI responses and consequently incomplete protection against virulent challenge, but when associated with the Mass vaccine, immune responses were developed, and complete protection against infection was observed. Both of our experimental vaccines were able to induce full protection against virulent IBV challenge. A single dose of AvCoV-CS vaccine was sufficient to achieve complete protection, while AvCoV-O required a previous priming by a Mass strain to complete the protection. MenosEfficient vaccines are the main strategy to control the avian coronavirus (AvCoV), although several drawbacks related to traditional attenuated and inactivated vaccines have been reported. These counterpoints highlight the importance of developing new alternative vaccines against AvCoV, especially those able to induce long-lasting immune responses. This study evaluated and compared two inactivated vaccines formulated with AvCoV BR-I variants, one composed of chitosan nanoparticles (AvCoV-CS) and the second by Montanide oily adjuvant (AvCoV-O). Both developed vaccines were administered in a single dose or associated with the traditional Mass attenuated vaccine. The AvCoV-CS vaccine administered alone or associated with the Mass vaccine was able to induce strong humoral and cell-mediated immune (CMI) responses and complete protection against IBV virulent infection, wherein single administration was characterized by high IgA antibody levels in the mucosa, whereas when associated with the Mass vaccine, the serum IgG antibody was predominantly observed. On the other hand, single administration of the oily vaccine presented poor humoral and CMI responses and consequently incomplete protection against virulent challenge, but when associated with the Mass vaccine, immune responses were developed, and complete protection against infection was observed. Both of our experimental vaccines were able to induce full protection against virulent IBV challenge. A single dose of AvCoV-CS vacci... Mostrar Tudo |
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Palavras-Chave: |
Avian infectious bronchitis; Cellular immune response; Delivery carrier adjuvant; Mucosal immunization; Oil adjuvant. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/228815/1/ComparativeEvaluationImmune.pdf
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Marc: |
LEADER 02553naa a2200277 a 4500
001 2137397
005 2021-12-09
008 2021 bl uuuu u00u1 u #d
022 $a2076-393X
024 7 $ahttps://doi.org/10.3390/vaccines9121457$2DOI
100 1 $aLOPES, P. D.
245 $aComparative evaluation of immune responses and protection of chitosan nanoparticles and oil-emulsion adjuvants in avian coronavirus inactivated vaccines in chickens.$h[electronic resource]
260 $c2021
520 $aEfficient vaccines are the main strategy to control the avian coronavirus (AvCoV), although several drawbacks related to traditional attenuated and inactivated vaccines have been reported. These counterpoints highlight the importance of developing new alternative vaccines against AvCoV, especially those able to induce long-lasting immune responses. This study evaluated and compared two inactivated vaccines formulated with AvCoV BR-I variants, one composed of chitosan nanoparticles (AvCoV-CS) and the second by Montanide oily adjuvant (AvCoV-O). Both developed vaccines were administered in a single dose or associated with the traditional Mass attenuated vaccine. The AvCoV-CS vaccine administered alone or associated with the Mass vaccine was able to induce strong humoral and cell-mediated immune (CMI) responses and complete protection against IBV virulent infection, wherein single administration was characterized by high IgA antibody levels in the mucosa, whereas when associated with the Mass vaccine, the serum IgG antibody was predominantly observed. On the other hand, single administration of the oily vaccine presented poor humoral and CMI responses and consequently incomplete protection against virulent challenge, but when associated with the Mass vaccine, immune responses were developed, and complete protection against infection was observed. Both of our experimental vaccines were able to induce full protection against virulent IBV challenge. A single dose of AvCoV-CS vaccine was sufficient to achieve complete protection, while AvCoV-O required a previous priming by a Mass strain to complete the protection.
653 $aAvian infectious bronchitis
653 $aCellular immune response
653 $aDelivery carrier adjuvant
653 $aMucosal immunization
653 $aOil adjuvant
700 1 $aOKINO, C. H.
700 1 $aFERNANDO, F. S.
700 1 $aPAVANI, C.
700 1 $aMARIGUELA, V. C.
700 1 $aMONTASSIER, M. DE F. S.
700 1 $aMONTASSIER, H. J.
773 $tVaccines$gv.9, n.12, 1457, 2021.
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Registro original: |
Embrapa Pecuária Sudeste (CPPSE) |
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Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
Voltar
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Registro Completo
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Biblioteca(s): |
Embrapa Meio Ambiente; Embrapa Soja. |
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Data corrente: |
11/03/2014 |
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Data da última atualização: |
19/11/2014 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
PYLRO, V. S.; ROESCH, L. F. W.; ORTEGA, J. M.; AMARAL, A. M. do; TÓTOLA, M. R.; HIRSCH, P. R.; ROSADO, A. S.; GÓES-NETO, A.; SILVA, A. L. da C.; ROSA, C. A.; MORAIS, D. K.; ANDREOTE, F. D.; DUARTE, G. F.; MELO, I. S. de; SELDIN, L.; LAMBAIS, M. R.; HUNGRIA, M.; PEIXOTO, R. S.; KRUGER, R. H.; TSAI, S. M.; AZEVEDO, V. |
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Afiliação: |
VICTOR SATLER PYLRO, UFV; LUIZ FERNANDO WURDIG ROESCH, UNIPAMPA; JOSÉ MIGUEL ORTEGA, UFMG; ALEXANDRE MORAIS DO AMARAL, SRI; MARCOS ROGÉRIO TÓTOLA, UFV; PENNY RUTH HIRSCH, Rothamsted Research; ALEXANDRE SOARES ROSADO, IMPPG/UFRJ; ARISTÓTELES GÓES-NETO, UEFS; ARTUR LUIZ DA COSTA DA SILVA, UFPA; CARLOS AUGUSTO ROSA, UFMG; DANIEL KUMAZAWA MORAIS, UFV; FERNANDO DINI ANDREOTE, ESALQ; GABRIELA FROIS DUARTE, UFOP; ITAMAR SOARES DE MELO, CNPMA; LUCY SELDIN, IMPPG/UFRJ; MÁRCIO RODRIGUES LAMBAIS, ESALQ; MARIANGELA HUNGRIA DA CUNHA, CNPSO; RAQUEL SILVA PEIXOTO, EMPPG/UFRJ; RICARDO HENRIQUE KRUGER, UNB; SIU MUI TSAI, CENA; VASCO AZEVEDO, UFMG. |
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Título: |
Brazilian microbiome project: revealing the unexplored microbial diversity - challenges and prospects. |
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Ano de publicação: |
2014 |
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Fonte/Imprenta: |
Microbial Ecology, New York, v. 67, n. 2, p. 237-241, Oct. 2014. |
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DOI: |
10.1007/s00248-013-0302-4 |
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Idioma: |
Inglês |
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Conteúdo: |
The Brazilian Microbiome Project (BMP) aims to assemble a Brazilian Metagenomic Consortium/Database. At present, many metagenomic projects underway in Brazil are widely known. Our goal in this initiative is to co-ordinate and standardize these together with new projects to come. It is estimated that Brazil hosts approximately 20 % of the entire world's macroorganism biological diversity. It is 1 of the 17 countries that share nearly 70 % of the world's catalogued animal and plant species, and is recognized as one of the most megadiverse countries. At the end of 2012, Brazil has joined GBIF (Global Biodiversity Information Facility), as associated member, to improve the access to the Brazilian biodiversity data in a free and open way. This was an important step toward increasing international collaboration and clearly shows the commitment of the Brazilian government in directing national policies toward sustainable development. Despite its importance, the Brazilian microbial diversity is still considered to be largely unknown, and it is clear that to maintain ecosystem dynamics and to sustainably manage land use, it is crucial to understand the biological and functional diversity of the system. This is the first attempt to collect and collate information about Brazilian microbial genetic and functional diversity in a systematic and holistic manner. The success of the BMP depends on a massive collaborative effort of both the Brazilian and international scientific communities, and therefore, we invite all colleagues to participate in this project. MenosThe Brazilian Microbiome Project (BMP) aims to assemble a Brazilian Metagenomic Consortium/Database. At present, many metagenomic projects underway in Brazil are widely known. Our goal in this initiative is to co-ordinate and standardize these together with new projects to come. It is estimated that Brazil hosts approximately 20 % of the entire world's macroorganism biological diversity. It is 1 of the 17 countries that share nearly 70 % of the world's catalogued animal and plant species, and is recognized as one of the most megadiverse countries. At the end of 2012, Brazil has joined GBIF (Global Biodiversity Information Facility), as associated member, to improve the access to the Brazilian biodiversity data in a free and open way. This was an important step toward increasing international collaboration and clearly shows the commitment of the Brazilian government in directing national policies toward sustainable development. Despite its importance, the Brazilian microbial diversity is still considered to be largely unknown, and it is clear that to maintain ecosystem dynamics and to sustainably manage land use, it is crucial to understand the biological and functional diversity of the system. This is the first attempt to collect and collate information about Brazilian microbial genetic and functional diversity in a systematic and holistic manner. The success of the BMP depends on a massive collaborative effort of both the Brazilian and international scientific communities, ... Mostrar Tudo |
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Palavras-Chave: |
Diversidade microbiana. |
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Thesagro: |
Análise Microbiológica; Biodiversidade; Microrganismo. |
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Thesaurus NAL: |
Biodiversity; Microbiome. |
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Categoria do assunto: |
S Ciências Biológicas
X Pesquisa, Tecnologia e Engenharia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/112036/1/2014AP020.pdf
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Marc: |
LEADER 02833naa a2200445 a 4500
001 2000621
005 2014-11-19
008 2014 bl uuuu u00u1 u #d
024 7 $a10.1007/s00248-013-0302-4$2DOI
100 1 $aPYLRO, V. S.
245 $aBrazilian microbiome project$brevealing the unexplored microbial diversity - challenges and prospects.$h[electronic resource]
260 $c2014
520 $aThe Brazilian Microbiome Project (BMP) aims to assemble a Brazilian Metagenomic Consortium/Database. At present, many metagenomic projects underway in Brazil are widely known. Our goal in this initiative is to co-ordinate and standardize these together with new projects to come. It is estimated that Brazil hosts approximately 20 % of the entire world's macroorganism biological diversity. It is 1 of the 17 countries that share nearly 70 % of the world's catalogued animal and plant species, and is recognized as one of the most megadiverse countries. At the end of 2012, Brazil has joined GBIF (Global Biodiversity Information Facility), as associated member, to improve the access to the Brazilian biodiversity data in a free and open way. This was an important step toward increasing international collaboration and clearly shows the commitment of the Brazilian government in directing national policies toward sustainable development. Despite its importance, the Brazilian microbial diversity is still considered to be largely unknown, and it is clear that to maintain ecosystem dynamics and to sustainably manage land use, it is crucial to understand the biological and functional diversity of the system. This is the first attempt to collect and collate information about Brazilian microbial genetic and functional diversity in a systematic and holistic manner. The success of the BMP depends on a massive collaborative effort of both the Brazilian and international scientific communities, and therefore, we invite all colleagues to participate in this project.
650 $aBiodiversity
650 $aMicrobiome
650 $aAnálise Microbiológica
650 $aBiodiversidade
650 $aMicrorganismo
653 $aDiversidade microbiana
700 1 $aROESCH, L. F. W.
700 1 $aORTEGA, J. M.
700 1 $aAMARAL, A. M. do
700 1 $aTÓTOLA, M. R.
700 1 $aHIRSCH, P. R.
700 1 $aROSADO, A. S.
700 1 $aGÓES-NETO, A.
700 1 $aSILVA, A. L. da C.
700 1 $aROSA, C. A.
700 1 $aMORAIS, D. K.
700 1 $aANDREOTE, F. D.
700 1 $aDUARTE, G. F.
700 1 $aMELO, I. S. de
700 1 $aSELDIN, L.
700 1 $aLAMBAIS, M. R.
700 1 $aHUNGRIA, M.
700 1 $aPEIXOTO, R. S.
700 1 $aKRUGER, R. H.
700 1 $aTSAI, S. M.
700 1 $aAZEVEDO, V.
773 $tMicrobial Ecology, New York$gv. 67, n. 2, p. 237-241, Oct. 2014.
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Embrapa Meio Ambiente (CNPMA) |
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